以细胞膜畸变的酵母突变体作为抗肿瘤抗生素的检测系统。
Yeast mutants with distorted cell membranes as a detection system for antitumor antibiotics.
作者信息
Gause G F, Laiko A V
出版信息
Antibiot Chemother (1971). 1978;23:21-5. doi: 10.1159/000401467.
PMID:348079
Abstract
Yeast mutants with distorted cell membranes, which are selectively inhibited by anticancer antibiotics and are not affected by antibacterial antibiotics, could be of considerable interest as test organisms. They could be used for the isolation of active antitumor substances from complex mixtures of natural compounds.
摘要
细胞膜变形的酵母突变体可作为测试生物体，具有相当大的研究价值。这类突变体对抗癌抗生素有选择性抑制作用，而不受抗菌抗生素的影响。它们可用于从天然化合物的复杂混合物中分离活性抗肿瘤物质。
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