Griffiths E, Cortes A, Gilbert N, Stevenson P, MacDonald S, Pepper D
National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK.
Lancet. 1995 Jan 21;345(8943):158-60. doi: 10.1016/s0140-6736(95)90168-x.
An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia coli septicaemia in mice, which draws attention to the potential danger of such products in the clinic.
一个很少受到关注的重要问题是，输注基于无细胞血红蛋白的血液替代品的患者可能会增加对细菌感染的易感性。我们发现，吡哆醛化聚合人血红蛋白会促使小鼠发生暴发性大肠杆菌败血症，这引起了人们对这类产品在临床上潜在危险的关注。
