Hanaoka T
Second Department of Surgery, Okayama University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1994 Oct;95(10):775-85.
The anti-thrombogenicity of argatroban and clopidogrel and the influence of these two agents on coagulation and fibrinolysis were investigated. After the infrarenal abdominal aorta of 21 dogs was replaced with a knitted Dacron prosthesis of 5 mm in internal diameter, the inner capsule of the graft was evaluated by angioscopy and angiography immediately and 1 week, 2 weeks and 1 month after surgery. The graft patency rate in group I (untreated group, n = 8), group II (argatroban group, postoperative infusion of 1 microgram/kg/min for 2 weeks, n = 7) and group III (clopidogrel group, postoperative oral administration of 12.5 mg/kg/day for 1 month, n = 6) was respectively 75%, 86% and 100% after 1 week; 75%, 86% and 100% after 2 weeks; and 50%, 71% and 100% after 1 month. The mean maximum stenosis measured by angioscopy was 31% in group I, 5% in group II and 4% in group III after 1 week; 52%, 23% and 13% after 2 weeks; and 61%, 40% and 9% after 1 month. An increase in thrombin antithrombin III complex (TAT) due to thrombus was observed in group I, but this was prevented in the treated groups. These results suggest that argatroban and clopidogrel are useful anti-thrombogenic agents for obtaining a thin inner capsule after graft implantation, especially in small caliber grafts.
研究了阿加曲班和氯吡格雷的抗血栓形成性以及这两种药物对凝血和纤溶的影响。在21只犬的肾下腹主动脉被内径为5mm的针织涤纶人工血管置换后，通过血管镜检查和血管造影术在术后即刻、1周、2周和1个月对移植物的内膜进行评估。I组（未治疗组，n = 8）、II组（阿加曲班组，术后以1μg/kg/min的速度输注2周，n = 7）和III组（氯吡格雷组，术后口服12.5mg/kg/天，持续1个月，n = 6）的移植物通畅率在1周后分别为75%、86%和100%；2周后分别为75%、86%和100%；1个月后分别为50%、71%和100%。血管镜检查测得的平均最大狭窄率在I组1周后为31%，II组为5%，III组为4%；2周后分别为52%、23%和13%；1个月后分别为61%、40%和9%。I组观察到由于血栓导致的凝血酶 - 抗凝血酶III复合物（TAT）增加，但在治疗组中这种情况得到了预防。这些结果表明，阿加曲班和氯吡格雷是在移植物植入后获得薄内膜的有用抗血栓形成药物，尤其是在小口径移植物中。
