Kosugi T, Masuda Y, Kinjoh K, Yamashita S, Sunagawa M, Nakamura M
Department of Physiology, University of the Ryukyus, Okinawa, Japan.
Int J Tissue React. 1995;17(3):109-16.
In the present study, we have investigated the effects of a synthetic antithrombin, Argatroban, and an antiplatelet agent. Ticlopidine hydrochloride, on the weight of artificial thrombus. These drugs at various concentrations were added to canine bloods, which were adjusted to 20%, 40% and 60% of haematocrit, and an artificial thrombus was formed using a modification of Chandler's method. Argatroban inhibited the formation of artificial thrombus, and this marked inhibition was observed especially in the experiment using blood with a high value of Ht. On the other hand, Ticlopidine hydrochloride did not inhibit the formation of artificial thrombus. From these results, it becomes clear that the mechanism of inhibitory action of Argatroban on artificial thrombus formation is based on the inhibition of thrombin activity and not on the inhibition of platelet aggregation. In addition, it is suggested that Argatroban inhibits the aggregation of red blood cells in the manner of direct or indirect action.
在本研究中，我们研究了合成抗凝血酶阿加曲班和抗血小板药物盐酸噻氯匹定对人工血栓重量的影响。将这些不同浓度的药物添加到犬血中，将犬血的血细胞比容分别调整为20%、40%和60%，并采用改良的钱德勒方法形成人工血栓。阿加曲班抑制人工血栓的形成，尤其在使用血细胞比容值高的血液进行的实验中观察到这种显著的抑制作用。另一方面，盐酸噻氯匹定不抑制人工血栓的形成。从这些结果可以清楚地看出，阿加曲班对人工血栓形成的抑制作用机制是基于对凝血酶活性的抑制，而不是基于对血小板聚集的抑制。此外，提示阿加曲班以直接或间接作用的方式抑制红细胞聚集。
