Willing A E, Koopmans H S, Walls E K
Department of Medical Science, University of Calgary, Alberta, Canada.
Physiol Behav. 1994 Nov;56(5):993-1001. doi: 10.1016/0031-9384(94)90334-4.
To test whether the route of insulin delivery has a major effect on the increase in daily food intake associated with chronic insulin treatment, insulin was continuously infused into either the vena cava (VC) or the hepatic portal (HP) vein of 23 diabetic Lewis rats. Increasing insulin doses in both the VC (2 to 6 U/day) and HP (1.5 to 3.5 U/day) groups significantly increased daily food intake (p < .05). Intake was higher in the VC group at 3 U/day but not at 2U/day. When insulin was delivered at a low fixed dose, daily food intake of both the VC and HP groups only increased after urinary glucose losses increased. The rate of weight gain increased significantly in the VC varied group (p < .05). Insulin administration also increased energy expenditure (p < .01). These results suggest that the extent of the increase in daily food intake and body weight that occurs with peripheral exogenous insulin administration is dependent on the route of infusion.
为了测试胰岛素给药途径是否对慢性胰岛素治疗相关的每日食物摄入量增加有重大影响，将胰岛素持续输注到23只糖尿病Lewis大鼠的腔静脉（VC）或肝门静脉（HP）中。VC组（2至6 U/天）和HP组（1.5至3.5 U/天）胰岛素剂量增加均显著增加每日食物摄入量（p < 0.05）。VC组在3 U/天时摄入量较高，但在2 U/天时并非如此。当以低固定剂量输注胰岛素时，只有在尿糖损失增加后，VC组和HP组的每日食物摄入量才会增加。VC可变组的体重增加率显著增加（p < 0.05）。胰岛素给药也增加了能量消耗（p < 0.01）。这些结果表明，外周给予外源性胰岛素时每日食物摄入量和体重增加的程度取决于输注途径。
