Willing A E, Walls E K, Koopmans H S
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Physiol Behav. 1990 Dec;48(6):893-8. doi: 10.1016/0031-9384(90)90245-y.
Current theories state that physiological levels of insulin inhibit daily food intake and reduce body weight. To test whether insulin induces satiety, systematically increasing doses of insulin from 2.0 to 5.0 U/day were infused intravenously into streptozotocin-induced diabetic rats. Food intake increased significantly from 70.0 +/- 1.4 kcal/day during the saline baseline up to 102.2 +/- 1.9 kcal/day in the 3.5 U/day insulin infusion and then stabilized at 95.9 +/- 0.5 kcal/day for the remaining doses (p less than 0.05). Retained energy values (kcal of food intake minus kcal of urinary glucose loss) also increased from 69.9 +/- 1.4 kcal/day to stabilize at 95 kcal/day (p less than 0.001). Food intake and retained energy of normal controls remained unchanged at 75.4 +/- 1.6 kcal/day for the duration of the study. With elevated food intake and retained energy values after the 3.5 U/day insulin dose, the diabetic rats gained more weight than the normal controls (p less than 0.01). Contrary to expectations, increasing the amount of insulin infused through the physiological range results in a 40% increase in daily food intake and a rapid gain in body weight.
当前理论认为，生理水平的胰岛素可抑制每日食物摄入量并减轻体重。为了测试胰岛素是否能诱导饱腹感，将胰岛素剂量从2.0单位/天系统性地增加至5.0单位/天，通过静脉注射给予链脲佐菌素诱导的糖尿病大鼠。食物摄入量从生理盐水基线期的70.0±1.4千卡/天显著增加至胰岛素输注量为3.5单位/天时的102.2±1.9千卡/天，然后在其余剂量下稳定在95.9±0.5千卡/天（p<0.05）。留存能量值（食物摄入量的千卡数减去尿葡萄糖损失的千卡数）也从69.9±1.4千卡/天增加至稳定在95千卡/天（p<0.001）。在研究期间，正常对照组的食物摄入量和留存能量保持在75.4±1.6千卡/天不变。在胰岛素剂量达到3.5单位/天后，糖尿病大鼠的食物摄入量和留存能量值升高，体重增加幅度大于正常对照组（p<0.01）。与预期相反，在生理范围内增加胰岛素输注量会导致每日食物摄入量增加40%，体重迅速增加。
