Batra M, Bernard S, Picha G
Department of Surgery, MetroHealth St. Luke's Medical Center, Cleveland, Ohio.
Plast Reconstr Surg. 1995 Feb;95(2):354-63. doi: 10.1097/00006534-199502000-00016.
The purpose of this study was to determine the soft-tissue response to silicone breast implants with different surface morphologies and to correlate implant microtexturing with capsular formation. Using a rat model, we inserted breast implants having three types of shells: micropillared, silicone foam, and smooth silicone (control). We used 96 adult male Sprague-Dawley rats weighing between 250 and 300 gm. Thirty-two rats were assigned to each of the three shell groups. Within each shell group, 4 rats were implanted for 24 hours, 4 for 4 weeks, 4 for 8 weeks, 4 for 12 weeks, 4 for 16 weeks, 4 for 20 weeks, and 4 for 24 weeks. The rats were sacrificed at the end of each time interval, and periprosthetic tissue was obtained for histologic analysis. Our results show a stable soft-tissue response with some macrophages and fibroblasts for the smooth silicone shell group; capsule thicknesses were 10 to 12 cells with interwoven collagen. The silicone foam prolonged the active cellular response with regard to macrophages, fibroblasts, and multinucleated giant cells, along with random collagen deposition and alternating thin and thick capsular areas. The micropillar group had a more stable cellular response, with macrophages and fibroblasts, along with disruption of the long-range orientation of collagen fibers.
本研究的目的是确定不同表面形态的硅胶乳房植入物的软组织反应，并将植入物的微纹理与包膜形成相关联。我们使用大鼠模型，植入了具有三种类型外壳的乳房植入物：微柱形、硅胶泡沫和光滑硅胶（对照）。我们使用了96只体重在250至300克之间的成年雄性Sprague-Dawley大鼠。将32只大鼠分配到三个外壳组中的每组。在每个外壳组中，4只大鼠植入24小时，4只植入4周，4只植入8周，4只植入12周，4只植入16周，4只植入20周，4只植入24周。在每个时间间隔结束时处死大鼠，并获取假体周围组织进行组织学分析。我们的结果显示，光滑硅胶外壳组有稳定的软组织反应，伴有一些巨噬细胞和成纤维细胞；包膜厚度为10至12个细胞，有交织的胶原蛋白。硅胶泡沫延长了巨噬细胞、成纤维细胞和多核巨细胞的活跃细胞反应，伴有随机的胶原蛋白沉积以及包膜区域的厚薄交替。微柱形组有更稳定的细胞反应，伴有巨噬细胞和成纤维细胞，以及胶原纤维长程取向的破坏。
