Vahlensieck M, Dombrowski F, Leutner C, Wagner U, Reiser M
Department of Radiology, University of Bonn, Germany.
Skeletal Radiol. 1994 Oct;23(7):535-9. doi: 10.1007/BF00223085.
Human articular cartilage from 16 cadaveric or amputated knees was studied using standard magnetic resonance imaging (MRI), on-resonance magnetization transfer contrast (MTC) and MTC-subtraction MRI. Results were compared with subsequent macroscopic and histopathological findings. MTC-subtraction and T2-weighted spin-echo images visualized cartilaginous surface defects with high sensitivity and specificity. MTC and T2-weighted spin-echo images revealed intra-cartilaginous signal loss without surface defects in 80% of the cases, corresponding to an increased collagen concentration. It is concluded that MTC is sensitive to early cartilage degeneration and MTC-subtraction can be helpful in detecting cartilage defects.
利用标准磁共振成像（MRI）、共振磁化转移对比（MTC）和MTC减影MRI对16个尸体或截肢膝关节的人体关节软骨进行了研究。将结果与随后的宏观和组织病理学发现进行了比较。MTC减影和T2加权自旋回波图像以高灵敏度和特异性显示软骨表面缺损。MTC和T2加权自旋回波图像在80%的病例中显示了无表面缺损的软骨内信号丢失，这与胶原浓度增加相对应。得出的结论是，MTC对早期软骨退变敏感，MTC减影有助于检测软骨缺损。
