Wu Z, Shaoji Z, Pan B, Hu L, Wei R, Gao Z, Li J, Uwe B
Jiangxi Provincial Institute o Parasitic Diseases, Nanchang, China.
Southeast Asian J Trop Med Public Health. 1994 Mar;25(1):163-9.
The study on reinfection with Schistosoma japonicum after treatment was carried out in a cohort of subjects in a heavy endemic village of Poyang lake region, China. After mass treatment with praziquantel in non-transmission time, detailed observations of water contact were estimated using the mean area of skin exposed daily. One year after treatment, the prevalence of infection in study subjects was 54.48%, returning to 83% of initial prevalence. The peak prevalence occurred the 11-15 year age class, but intensity of exposure also varies with age and that age group supporting the higher prevalence of reinfection had high levels of exposure. Among groups of subjects with a similar exposure stratum, young subjects under the age of 21 years were more heavily reinfected, while no heavy reinfection was observed in adults (> or = 25 years). These observations suggest that subjects in this area slowly acquire an increasing degree of immunity to lighten the intensity of infection with S. japonicum.
在中国鄱阳湖地区一个血吸虫病重流行村的一组研究对象中开展了治疗后日本血吸虫再感染的研究。在非传播季节用吡喹酮进行大规模治疗后，通过每日暴露皮肤的平均面积对接触水的情况进行了详细观察。治疗一年后，研究对象的感染率为54.48%，回升至初始感染率的83%。感染率高峰出现在11 - 15岁年龄组，但暴露强度也随年龄变化，支持再感染较高发生率的该年龄组有较高的暴露水平。在暴露水平相似的研究对象组中，21岁以下的年轻对象再感染更严重，而在成年人（≥25岁）中未观察到严重再感染。这些观察结果表明，该地区的研究对象逐渐获得了越来越强的免疫力，从而减轻了日本血吸虫的感染强度。
