新型抗链霉素大肠杆菌突变体

New types of streptomycin-resistant mutants of Escherichia coli.

作者信息

Lacoste L, Lacaille M, Brakier-Gingras L

出版信息

Biochim Biophys Acta. 1976 Aug 2;442(1):88-97. doi: 10.1016/0005-2787(76)90179-9.

DOI:10.1016/0005-2787(76)90179-9

Abstract

Mutagenesis of Escherichia coli K12 cells with ethyl methanesulfonate and selection of streptomycin-resistant mutants after a long delay for phenotypic expression allowed us to isolate new types of streptomycin-resistant ribosomes. Misreading patterns of the ribosomes in the presence of streptomycin revealed that most of the streptomycin-resistant mutants isolated under these conditions differed from the four classical types of streptomycin-resistant mutants studied and characterized by Strigini, P. and Gorini, L. (1970) J. Mol. Biol. 47, 517-530.

摘要

用甲磺酸乙酯对大肠杆菌K12细胞进行诱变，并在长时间延迟以实现表型表达后筛选出链霉素抗性突变体，这使我们能够分离出新型的链霉素抗性核糖体。在链霉素存在的情况下核糖体的错读模式表明，在这些条件下分离出的大多数链霉素抗性突变体与Strigini, P.和Gorini, L.（1970年，《分子生物学杂志》47卷，517 - 530页）所研究和表征的四种经典类型的链霉素抗性突变体不同。

相似文献

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New types of streptomycin-resistant mutants of Escherichia coli.新型抗链霉素大肠杆菌突变体

Biochim Biophys Acta. 1976 Aug 2;442(1):88-97. doi: 10.1016/0005-2787(76)90179-9.

2

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The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli.错修复过程在大肠杆菌新型链霉素抗性突变体分离中的作用。

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A slow-growing, streptomycin resistant mutant of Escherichia coli affected in protein synthesis and ribosomal assembly.一种生长缓慢、对链霉素耐药的大肠杆菌突变体，其蛋白质合成和核糖体组装受到影响。

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Science. 1968 Aug 2;161(3840):478-9. doi: 10.1126/science.161.3840.478.

引用本文的文献

1

The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli.错修复过程在大肠杆菌新型链霉素抗性突变体分离中的作用。

Mol Gen Genet. 1977 Dec 9;157(3):313-8. doi: 10.1007/BF00268668.

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