Lacoste L, Lacaille M, Brakier-Gingras L
Mol Gen Genet. 1977 Dec 9;157(3):313-8. doi: 10.1007/BF00268668.
Treatment of Escherichia coli cells with ethylmethanesulfonate followed by a prolonged delay for phenotypic expression allows to select new types of streptomycin-resistant mutants, which are double mutants with one change resulting from base mispairing and the second one from misrepair. The error-prone recA-dependent pathway is involved in this misrepair, as evidenced by the fact that recA strains do not provide double mutants.
用甲磺酸乙酯处理大肠杆菌细胞，随后长时间延迟表型表达，可筛选出新类型的链霉素抗性突变体，这些突变体是双突变体，一个变化源于碱基错配，另一个源于错配修复。易错的recA依赖途径参与了这种错配修复，recA菌株不能产生双突变体这一事实证明了这一点。
