Gorini L, Rosset R, Zimmermann R A
Science. 1967 Sep 15;157(3794):1314-7. doi: 10.1126/science.157.3794.1314.
In attempting to define the role of ribosomes in the mechanism of streptomycin dependence, a new phenomenon has been discovered. Analysis of this phenomenon-called phenotypic masking-leads to the conclusion that "streptomycin dependent" mutants are actually "drug dependent" because their dependence is equally satisfied by several drugs. These drugs, some of which are totally unrelated chemically, act on the ribosome and induce misreading in vitro and suppression in vivo.
在试图确定核糖体在链霉素依赖性机制中的作用时，发现了一种新现象。对这种称为表型掩盖的现象进行分析后得出结论：“链霉素依赖性”突变体实际上是“药物依赖性”的，因为它们对几种药物的依赖性同样得到满足。这些药物，其中一些在化学上完全无关，作用于核糖体并在体外诱导错读，在体内诱导抑制。
