Chudinova V V, Alekseev S M, Zakharova E I, Evstigneeva R P
Bioorg Khim. 1994 Oct;20(10):1029-46.
Data concerning lipid peroxidation and mechanism of the vitamin E inhibiting action are reviewed. Steps of initiated lipid autooxidation, formation of primary and secondary oxidation products, destabilizing the membrane structure and possessing cytotoxic effects are described. The mechanism of the antioxidant action of alpha-tocopherol, dependence of its activity on the structure and composition of the products of cooxidation of lipids and alpha-tocopherol in biological and model systems are also discussed.
本文综述了有关脂质过氧化以及维生素E抑制作用机制的数据。文中描述了引发脂质自动氧化的步骤、一级和二级氧化产物的形成，这些产物会破坏膜结构并具有细胞毒性作用。同时还讨论了α-生育酚的抗氧化作用机制，以及其活性在生物和模型系统中对脂质与α-生育酚共氧化产物的结构和组成的依赖性。
