Drife J O, McClelland D B, Pryde A, Roberts M M, Smith I I
Br Med J. 1976 Aug 28;2(6034):503-6. doi: 10.1136/bmj.2.6034.503.
Nulliparous women have a greater risk of developing breast cancer than women who have borne children, but so far no functional differences in breast tissue have been reported between parous women and nulliparae. Macroscopically and histologically normal breast tissue was obtained from 74 women of reproductive age during biopsy of benign breast lesions and was examined for the presence of plasma cells by immunfluorescence. Immunoglobulin synthesis was detected by an in-vitro culture technique. Synthesis of IgA was detected in 81% of specimans of IgG in 45%, and of IgM in 3%. IgA synthesis much more intense than IgG or IgM synthesis. Plasma cells containing IgA were seen in 71% of the specimens examined, and 88% of specimens had deposits of IgA in the ductules. The findings were not significantly incluenced by the nature of the condition necessitating biopsy or by oral contraception. Nulliparous women showed no cyclical changes, but among parous women IgA synthesis was more intense during luteal phase of the menstrual cycle. This suggests that after the first pregnancy the breast is more sensitive to progesterone.
未生育女性患乳腺癌的风险高于已生育女性，但迄今为止，尚未有关于经产妇和未产妇乳腺组织功能差异的报道。在对良性乳腺病变进行活检期间，从74名育龄女性身上获取了宏观和组织学上均正常的乳腺组织，并通过免疫荧光检查浆细胞的存在情况。采用体外培养技术检测免疫球蛋白的合成。在81%的标本中检测到IgA合成，45%的标本中检测到IgG合成，3%的标本中检测到IgM合成。IgA合成比IgG或IgM合成强烈得多。在71%的检查标本中可见含IgA的浆细胞，88%的标本在小导管中有IgA沉积。这些发现不受活检所需病情性质或口服避孕药的显著影响。未生育女性未表现出周期性变化，但在经产妇中，IgA合成在月经周期的黄体期更为强烈。这表明首次怀孕后，乳腺对孕酮更为敏感。
