Iannello R C, Young J C, Kola I
Molecular Embryology and Birth Defects Laboratory, Monash Medical Centre, Clayton, Victoria, Australia.
Mol Reprod Dev. 1994 Oct;39(2):194-9. doi: 10.1002/mrd.1080390212.
Precise temporal and tissue-specific expression of genes during spermatocyte differentiation is crucial for the formation of functional spermatozoa. However, the mechanisms that regulate gene expression during spermatogenesis are poorly understood. One testis-specific gene, Pdha-2, is beginning to emerge as a potentially important model for the study of these events. This review focuses on our current understanding of the expression and regulation of Pdha-2 during spermatogenesis.
精子细胞分化过程中基因精确的时间和组织特异性表达对于功能性精子的形成至关重要。然而，精子发生过程中调控基因表达的机制仍知之甚少。一个睾丸特异性基因Pdha-2，正逐渐成为研究这些事件的一个潜在重要模型。这篇综述聚焦于我们目前对精子发生过程中Pdha-2表达和调控的理解。
