Cook E H, Metz J, Leventhal B L, Lebovitz M, Nathan M, Semerdjian S A, Brown T, Cooper M D
Department of Psychaitry, University of Chicago, IL 60637.
Neuroreport. 1994 Sep 8;5(14):1745-8. doi: 10.1097/00001756-199409080-00014.
In a counterbalanced, double-blind, placebo-controlled trial, 40 mg of fluoxetine was administered to four healthy adult volunteers (three men, one woman; age range 20-39 years), 90 min before injection of 6-7.5 mCi of [18F]-2-deoxyglucose to measure cerebral metabolic rate of glucose (CMRglu). Subjects were engaged in a visual monitoring task shortly before and during scanning with a PETT-VI tomograph. Global CMRglu did not differ when placebo (8.93 +/- 0.96 mg 100 g-1 min-1) was compared to fluoxetine (8.22 +/- 0.86 mg 100 g-1 min-1; paired t-test = 0.82, df = 3, p < 0.48). However, statistical parametric mapping of differences in CMRglu between placebo and fluoxetine conditions revealed regional effects of fluoxetine shown by decreased metabolism in the amygdaloid complex, hippocampal formation and ventral striatum, and by increased metabolism centered in the right superior parietal lobe (Brodmann area 7). Parametric mapping for use in PET studies of glucose metabolism represents a significant new tool for studying drug effects in humans.
在一项采用平衡、双盲、安慰剂对照的试验中，在向4名健康成年志愿者（3名男性，1名女性；年龄范围20 - 39岁）注射6 - 7.5毫居里的[18F]-2-脱氧葡萄糖以测量脑葡萄糖代谢率（CMRglu）前90分钟，给他们服用40毫克氟西汀。在使用PETT-VI断层扫描仪进行扫描之前及扫描过程中，受试者参与一项视觉监测任务。当将安慰剂组（8.93 +/- 0.96毫克100克-1分钟-1）与氟西汀组（8.22 +/- 0.86毫克100克-1分钟-1；配对t检验= 0.82，自由度= 3，p < 0.48）进行比较时，整体CMRglu并无差异。然而，安慰剂组与氟西汀组之间CMRglu差异的统计参数映射显示，氟西汀具有区域效应，表现为杏仁复合体、海马结构和腹侧纹状体代谢降低，以及以右侧顶上叶（布罗德曼7区）为中心的代谢增加。用于葡萄糖代谢PET研究的参数映射是研究药物对人体作用的一项重要新工具。
