Edvinsson L, Goadsby P J
Department of Internal Medicine, University Hospital, Lund, Sweden.
Cephalalgia. 1994 Oct;14(5):320-7. doi: 10.1046/j.1468-2982.1994.1405320.x.
The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.
大脑循环由动脉、小动脉和静脉中富含神经肽Y（NPY）和去甲肾上腺素的交感神经纤维丰富网络所支配。然而，含血管活性肠肽（VIP）、P物质（SP）和降钙素基因相关肽（CGRP）的纤维的神经供应稀少。去甲肾上腺素和NPY引起血管收缩，而VIP、SP和CGRP是强效血管扩张剂。刺激猫和人的三叉神经节会引发SP和CGRP的释放。偏头痛自发发作的患者显示CGRP的释放与头痛同时出现。丛集性头痛患者在发作期间有CGRP和VIP的释放。舒马曲坦治疗可终止偏头痛和丛集性头痛的头痛发作以及伴随的肽释放。
