Spencer N J, Evans A J, Galea M, Sibbering D M, Yeoman L J, Pinder S E, Ellis I O, Elston C W, Blamey R W, Robertson J F
Helen Garrod Breast Screening Unit, City Hospital, Nottingham.
Clin Radiol. 1994 Dec;49(12):853-6. doi: 10.1016/s0009-9260(05)82874-0.
Benign biopsies are an inevitable part of any screening programme. They add significantly to the psychological and financial 'cost' of screening and so should be kept to a minimum. To identify possible means of reducing these false positive results we have reviewed the mammographic features of 108 benign lesions removed during prevalent round screening and correlations were sought with the pathological findings. The commonest mammographic abnormalities leading to benign biopsy were non-comedo type suspicious calcification (29%), poorly defined mass (21%), architectural distortion (19%) and a well defined mass (18%). The histological correlates were: non-comedo type suspicious calcification (fibrocystic change 60%, sclerosing adenosis 35%, and radial scar/CSL 13%), poorly defined masses (fibrocystic change 37%, fibroadenomas 37%, and sclerosing adenosis 25%) and architectural distortion (radial scar/CSL 61% and fibrocystic change 26%). Methods of reducing screening provoked benign biopsies are discussed.
良性活检是任何筛查项目中不可避免的一部分。它们显著增加了筛查的心理和经济“成本”，因此应尽量减少。为了确定减少这些假阳性结果的可能方法，我们回顾了在普查轮次筛查期间切除的108例良性病变的乳腺X线特征，并寻求与病理结果的相关性。导致良性活检的最常见乳腺X线异常为非粉刺型可疑钙化（29%）、边界不清的肿块（21%）、结构扭曲（19%）和边界清晰的肿块（18%）。组织学相关性为：非粉刺型可疑钙化（纤维囊性变60%、硬化性腺病35%、放射状瘢痕/复杂性硬化性病变13%）、边界不清的肿块（纤维囊性变37%、纤维腺瘤37%、硬化性腺病25%）和结构扭曲（放射状瘢痕/复杂性硬化性病变61%、纤维囊性变26%）。本文讨论了减少筛查引发的良性活检的方法。
