多不饱和脂肪酸对幽门螺杆菌生长的抑制作用：饮食对消化性溃疡影响的一种可能解释。
Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration.
作者信息
Thompson L, Cockayne A, Spiller R C
机构信息
Department of Therapeutics, University Hospital, Nottingham.
出版信息
Gut. 1994 Nov;35(11):1557-61. doi: 10.1136/gut.35.11.1557.
Abstract
Diets high in polyunsaturated fatty acids may protect against duodenal ulcer, possibly through inhibiting the growth of Helicobacter pylori. This hypothesis was tested in vitro by incubating H pylori microaerophilically with a range of polyunsaturated fatty acids. omega-3 Linolenic acid significantly, but reversibly, inhibited growth at 1.8, 2.5, and 5 x 10(-4) M (p < 0.01), while concentrations of 10(-3) M killed virtually all organisms, with cell lysis observed by electron microscopy. Similar inhibitory effects were seen with other polyunsaturated fatty acids, at concentrations of 2.5 x 10(-4) M the relative inhibitory potencies were oleic (C18:1) < linoleic (C18:2) < arachidonic (C20:4) < omega-3 linolenic (C18:3) = omega-6 linolenic (C18:3) = eicosapentanoic (C20:5) acid. Cell fractionation studies with 14C labelled linolenic acid showed that the linolenic acid was associated with the membrane fraction. Commonly ingested dietary polyunsaturated fatty acids inhibit the growth of H pylori in vitro, an effect which deserves further in vivo study.
摘要
富含多不饱和脂肪酸的饮食可能预防十二指肠溃疡，可能是通过抑制幽门螺杆菌的生长来实现的。该假设通过在微需氧条件下将幽门螺杆菌与一系列多不饱和脂肪酸一起孵育进行体外试验。ω-3亚麻酸在1.8、2.5和5×10⁻⁴M时显著但可逆地抑制生长（p<0.01），而10⁻³M的浓度几乎杀死所有微生物，通过电子显微镜观察到细胞裂解。其他多不饱和脂肪酸也有类似的抑制作用，在2.5×10⁻⁴M浓度下，相对抑制效力为油酸（C18:1）<亚油酸（C18:2）<花生四烯酸（C20:4）<ω-3亚麻酸（C18:3）=ω-6亚麻酸（C18:3）=二十碳五烯酸（C20:5）。用¹⁴C标记的亚麻酸进行的细胞分级分离研究表明，亚麻酸与膜部分相关。常见的饮食中摄入的多不饱和脂肪酸在体外抑制幽门螺杆菌的生长，这一效应值得进一步进行体内研究。
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