肛管上皮内瘤变组织病理学分级报告中的观察者间差异。
Interobserver variation in the reporting of the histopathological grading of anal intraepithelial neoplasia.
作者信息
Carter P S, Sheffield J P, Shepherd N, Melcher D H, Jenkins D, Ewings P, Talbot I, Northover J M
机构信息
Colorectal Cancer Unit, St Mark's Hospital, London.
出版信息
J Clin Pathol. 1994 Nov;47(11):1032-4. doi: 10.1136/jcp.47.11.1032.
Abstract
AIM
To assess the consistency in the histological reporting of anal intraepithelial neoplasia (AIN) among experienced histopathologists.
METHOD
One hundred anal biopsy specimens were retrieved from archival material at St Mark's Hospital, London and graded by five histopathologists according to criteria outlined by Fenger (six point scale, ranging from normal to invasive carcinoma).
RESULTS
There was only moderate agreement among the pathologists, with unweighted k scores ranging from 0.09 to 0.48, and weighted k scores of 0.17 to 0.60.
CONCLUSIONS
There is considerable interobserver variation in the reporting of AIN. A simplified system of grading may help to abolish this.
摘要
目的
评估经验丰富的组织病理学家对肛管上皮内瘤变（AIN）进行组织学报告时的一致性。
方法
从伦敦圣马克医院的存档材料中获取100份肛管活检标本，并由5位组织病理学家根据芬格提出的标准（六点量表，范围从正常到浸润性癌）进行分级。
结果
病理学家之间只有中等程度的一致性，未加权的k值范围为0.09至0.48，加权的k值为0.17至0.60。
结论
在AIN报告中存在相当大的观察者间差异。简化的分级系统可能有助于消除这一现象。
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