通过口服猪胰岛素抑制非肥胖糖尿病小鼠的糖尿病症状。 - Suppr

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超能文献

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

作者信息

Carel J C, Bougnères P, Vardi P

机构信息

INSERM U342 and Endocrinologie Pédiatrique, Hôpital Saint Vincent de Paul, Paris.

出版信息

J Endocrinol Invest. 1994 Jul-Aug;17(7):573-80. doi: 10.1007/BF03347752.

DOI:10.1007/BF03347752

PMID:7829832

Abstract

摘要

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Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.通过口服猪胰岛素抑制非肥胖糖尿病小鼠的糖尿病症状。

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Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

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Prevention of diabetes in the nonobese diabetic mouse by oral immunological treatments. Comparative efficiency of human insulin and two bacterial antigens, lipopolysacharide from Escherichia coli and glycoprotein extract from Klebsiella pneumoniae.通过口服免疫疗法预防非肥胖糖尿病小鼠患糖尿病。人胰岛素与两种细菌抗原（大肠杆菌脂多糖和肺炎克雷伯菌糖蛋白提取物）的比较效果。

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Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse.口服胰岛素（人源、鼠源或猪源）不能预防非肥胖糖尿病小鼠患糖尿病。

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Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference.口服免疫“耐受”中的胰岛素：B链上一个氨基酸的变化起了关键作用。

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Oral use of interferon-alpha delays the onset of insulin-dependent diabetes mellitus in nonobese diabetes mice.口服α-干扰素可延缓非肥胖型糖尿病小鼠胰岛素依赖型糖尿病的发病。

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Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes.给非肥胖糖尿病（NOD）小鼠口服人胰岛素会产生可抑制糖尿病过继转移的CD4 + T细胞。

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Oral insulin for diabetes prevention in NOD mice: potentiation by enhancing Th2 cytokine expression in the gut through bacterial adjuvant.口服胰岛素预防非肥胖糖尿病（NOD）小鼠糖尿病：通过细菌佐剂增强肠道Th2细胞因子表达来增强效果

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Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.代谢无活性的胰岛素类似物不能预防非肥胖糖尿病（NOD）小鼠的自身免疫性糖尿病。

Diabetologia. 2017 Aug;60(8):1475-1482. doi: 10.1007/s00125-017-4276-5. Epub 2017 Apr 28.

Engineering the gut for insulin replacement to treat diabetes.工程化肠道用于胰岛素替代治疗糖尿病。

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本文引用的文献

The regulation of immune responses to dietary protein antigens.对膳食蛋白质抗原的免疫反应调节。

Immunol Today. 1987;8(3):93-8. doi: 10.1016/0167-5699(87)90853-X.

Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.近期发病的胰岛素依赖型糖尿病中β细胞葡萄糖转运蛋白2（GLUT-2）的自身抗体。

Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1281-4. doi: 10.1073/pnas.90.4.1281.

Effects of oral administration of type II collagen on rheumatoid arthritis.口服II型胶原蛋白对类风湿性关节炎的影响。

Science. 1993 Sep 24;261(5129):1727-30. doi: 10.1126/science.8378772.

Treating arthritis with tolerance.以耐受性治疗关节炎。

Science. 1993 Sep 24;261(5129):1669-70. doi: 10.1126/science.8378767.

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.胰岛细胞自身抗原69kD（ICA69）。一种新型糖尿病相关自身抗原的分子克隆与特性分析。

J Clin Invest. 1993 Jul;92(1):359-71. doi: 10.1172/JCI116574.

Detection of heat shock protein in patients with insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病患者热休克蛋白的检测

Diabetes Res Clin Pract. 1993 Jul;21(1):25-9. doi: 10.1016/0168-8227(93)90093-k.

Treatment of autoimmune diseases by oral tolerance to autoantigens.通过对自身抗原的口服耐受来治疗自身免疫性疾病。

Autoimmunity. 1993;15 Suppl:6-7. doi: 10.3109/08916939309008850.

Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.多发性硬化症中髓鞘抗原口服耐受的双盲试点试验。

Science. 1993 Feb 26;259(5099):1321-4. doi: 10.1126/science.7680493.

The design of trials for prevention of IDDM.

Diabetes. 1993 Jul;42(7):941-7. doi: 10.2337/diab.42.7.941.

A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones.

Hum Mol Genet. 1993 Nov;2(11):1793-8. doi: 10.1093/hmg/2.11.1793.

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