Imagawa Y, Fukuyama M, Kawakami K, Suda O
College of Environmental Health, Azabu University.
Kansenshogaku Zasshi. 1994 Nov;68(11):1409-16. doi: 10.11150/kansenshogakuzasshi1970.68.1409.
Antibacterial activity of fleroxacin (FLRX), a new quinolone antimicrobial, against 36 strains of Shigella app., 14 strains of Salmonella spp., 11 strains of Escherichia coli, 9 strains of Vibrio spp. (including 2 strains of V. cholerae O1), 14 strains of Campylobacter jejuni/coli, 3 strains of Aeromonas spp. and 1 strain of Plesiomonas shigelloides isolated from infectious enteritis patients in this study was determined. Its activity was compared with that of ciprofloxacin (CPFX), norfloxacin (NFLX) and nalidixic acid (NA). The MIC90 values of FLRX were 0.1 microgram/ml against Shigella spp. and E. coli, 0.2 microgram/ml against Salmonella spp. and Vibrio spp., and 12.5 micrograms/ml against C. jejuni/coli MIC90 of FLRX was comparable to that of CPFX and NFLX against Vibrio spp.. Against other species, MIC90 of FLRX were 2- to 4-fold higher than those of CPFX, whereas equal to or 2-fold lower than NFLX. FLRX demonstrated excellent activity against an NA-resistant (MIC: > 100 micrograms/ml) isolate of E. coli, with MIC 0.78 microgram/ml. FLRX showed 8-fold higher activity than NA against other strains. The antibacterial activity of FLRX was compared with that of NA against stocked strains (clinical isolates from August 1989 to February 1991), consisting of 11 strains of Shigella spp., 10 strains of Salmonella spp., 8 strains of E. coli, 10 strains of V. cholerae O1, 10 strains of V. parahaemolyticus and 14 strains of C. jejuni/coli. MICs of FLRX were 0.78 and 12.5-25 micrograms/ml against Shigella spp. and C. jejuni/coli that showed resistance of NA (MIC: > or = 100 micrograms/ml), respectively. Based on the above, although the absolute MICs are low against E. coli and shigella spp., a value of 0.78 micrograms/ml for FLRX suggested that such strains should be considered to be resistant.
测定了新型喹诺酮类抗菌药氟罗沙星（FLRX）对本研究中从感染性肠炎患者分离出的36株志贺菌属、14株沙门菌属、11株大肠埃希菌、9株弧菌属（包括2株霍乱弧菌O1）、14株空肠弯曲菌/结肠弯曲菌、3株气单胞菌属和1株类志贺邻单胞菌的抗菌活性。将其活性与环丙沙星（CPFX）、诺氟沙星（NFLX）和萘啶酸（NA）进行了比较。FLRX对志贺菌属和大肠埃希菌的MIC90值为0.1微克/毫升，对沙门菌属和弧菌属为0.2微克/毫升，对空肠弯曲菌/结肠弯曲菌为12.5微克/毫升。FLRX对弧菌属的MIC90与CPFX和NFLX相当。对其他菌属，FLRX的MIC90比CPFX高2至4倍，而与NFLX相当或低2倍。FLRX对一株萘啶酸耐药（MIC：>100微克/毫升）的大肠埃希菌表现出优异的活性，MIC为0.78微克/毫升。FLRX对其他菌株的活性比萘啶酸高8倍。将FLRX的抗菌活性与萘啶酸对保藏菌株（1989年8月至1991年2月的临床分离株）的抗菌活性进行了比较, 保藏菌株包括11株志贺菌属、10株沙门菌属、8株大肠埃希菌、10株霍乱弧菌O1、10株副溶血性弧菌和14株空肠弯曲菌/结肠弯曲菌。FLRX对萘啶酸耐药（MIC：>或=100微克/毫升）的志贺菌属和空肠弯曲菌/结肠弯曲菌的MIC分别为0.78和12.5 - 25微克/毫升。基于以上情况，虽然FLRX对大肠埃希菌和志贺菌属的绝对MIC值较低，但0.78微克/毫升的值表明此类菌株应被视为耐药。
