Shimada M, Takenaka K, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Chemother. 1994 Aug;6(4):251-6. doi: 10.1080/1120009x.1994.11741161.
The effect of flomoxef as empiric therapy for surgical infections of the digestive organs was analyzed in 103 patients, most of whom (94.2%) had intra-abdominal infections. Surgical procedures were performed on 73 patients contemporaneously with the flomoxef therapy. Flomoxef is an oxacephem and has a potent and broad bactericidal spectrum against aerobes and anaerobes. It provokes fewer adverse reactions than latamoxef such as vitamin K deficiency and platelet dysfunction. Flomoxef was administered intravenously at a dose 1-4g/day for more than 3 days without any other antimicrobial agent. The clinical response was classified into 3 groups; cured, improved and failed, and both the cured and improved responses were defined as satisfactory. A satisfactory response was obtained in 99 patients (96.1%). Regarding bacteriological response, the overall eradication rate was 81.3%. Adverse reactions including abnormal laboratory data occurred in only two patients. One had abdominal pain, and the other had a mild elevation of transaminases, and both were mild and easily reversible. Therefore, flomoxef is considered to have the potential of becoming one of the most effective agents in empiric therapy for surgical infections of the digestive organs.
对103例患者分析了氟氧头孢作为消化系统器官外科感染经验性治疗药物的效果，其中大多数患者（94.2%）患有腹腔内感染。73例患者在接受氟氧头孢治疗的同时进行了外科手术。氟氧头孢是一种氧头孢烯类药物，对需氧菌和厌氧菌具有强大而广泛的杀菌谱。与拉氧头孢相比，它引起的不良反应较少，如维生素K缺乏和血小板功能障碍。氟氧头孢静脉给药，剂量为1-4g/天，持续3天以上，未使用任何其他抗菌药物。临床反应分为3组：治愈、改善和失败，治愈和改善反应均定义为满意。99例患者（96.1%）获得了满意的反应。在细菌学反应方面，总体根除率为81.3%。仅2例患者出现包括实验室数据异常在内的不良反应。1例患者出现腹痛，另1例患者转氨酶轻度升高，均为轻度且易于逆转。因此，氟氧头孢被认为有潜力成为消化系统器官外科感染经验性治疗中最有效的药物之一。
