肾移植受者中锝-99m-L,L-乙半胱氨酸的评估：与锝-99m-巯基乙酰三甘氨酸和碘-125-邻碘马尿酸的对比研究

Evaluation of technetium-99m-L,L-EC in renal transplant recipients: a comparative study with technetium-99m-MAG3 and iodine-125-OIH.

作者信息

Stoffel M, Jamar F, Van Nerom C, Verbruggen A, Mourad M, Leners N, Squifflet J P, Beckers C

机构信息

Center of Nuclear Medicine, University of Louvain Medical School, Brussels; Belgium.

出版信息

J Nucl Med. 1994 Dec;35(12):1951-8.

PMID:7989976

Abstract

UNLABELLED

The clinical usefulness of kit-formulated 99mTc-L,L-EC, a new renal tubular tracer agent based on a diaminodithiol ligand was evaluated in a large population of renal transplant recipients.

METHODS

Fifty patients with transplants were studied. Five patients with renal insufficiency and five normal volunteers were also included to extend the range of renal function values. The labeling efficiency of 99mTc-L,L-EC in routine conditions, i.e., without HPLC purification, and the safety of the tracer were evaluated.

RESULTS

The mean radiochemical purity of 99mTc-L,L-EC determined by thin-layer chromatography was 97.4%. No side effects or significant biochemical changes were observed. The clearance of 99mTc-L,L-EC and 125I-OIH ranged from 10.7 to 417.5 and from 27.6 to 602.7 ml/min/1.73 m2, respectively. The clearance of 99mTc-L,L-EC and 99mTc-MAG3 averaged respectively 71% and 52% of that of 125I-OIH.

CONCLUSION

The labeling procedure of kit-formulated 99mTc-L,L-EC is easy and efficient. This tracer is safe and suitable for both imaging and quantitative measurement of the renal tubular function. Technetium-99m-L,L-EC represents an excellent alternative to 99mTc-MAG3.

摘要

未标记

基于二氨基二硫醇配体的新型肾小管示踪剂试剂盒配制的99mTc-L,L-EC在大量肾移植受者中的临床实用性得到评估。

方法

对50例移植患者进行研究。还纳入了5例肾功能不全患者和5名正常志愿者以扩大肾功能值范围。评估了常规条件下（即不进行高效液相色谱纯化）99mTc-L,L-EC的标记效率以及该示踪剂的安全性。

结果

通过薄层色谱法测定的99mTc-L,L-EC的平均放射化学纯度为97.4%。未观察到副作用或显著的生化变化。99mTc-L,L-EC和125I-OIH的清除率分别为10.7至417.5和27.6至602.7 ml/min/1.73 m2。99mTc-L,L-EC和99mTc-MAG3的清除率分别平均为125I-OIH清除率的71%和52%。