Bilder G E
Immunol Commun. 1976;5(3):163-79. doi: 10.3109/08820137609044273.
Immune competence (as determined by xenograft rejection) was measured following classical endocrine ablation and replacement procedures in the adult rat. Graft rejection, expressed as initial rejection time, was not changed by thyroidectomy, adrenalectomy, or hypophysectomy, either with or without appropriate hormone replacement. In concrast, gonadectomy in 3 rat types (female Sprague-Dawley, male and female Long Evans) decreased initial rejection time; administration of physiological doses of 17beta-estradiol plus progesterone returned the initial rejection time of ovariectomized rats to that observed in unoperated controls. Since initial rejection time was neither decreased by secondary ovariectomy (hypophysectomy) nor increased by sex steroid administration to hypophysectomized rats, it was suggested that the increased immune response after ovariectomy may be due to the presence of an immunopotentiating pituitary factor(s). Although commerical preparations of follicle-stimulating hormone, luteinizing hormone, and luteotropic hormone were found to mimic the effect of ovariectomy, the impurity of these preparations (as judged by isoelectric focusing gels) precluded any conclusion as to the nature of the postulated immunopotentiating factor.
在成年大鼠中，按照经典的内分泌切除和替代程序，测定免疫能力（通过异种移植排斥反应确定）。以初始排斥时间表示的移植排斥反应，无论有无适当的激素替代，甲状腺切除术、肾上腺切除术或垂体切除术均未改变。相比之下，三种大鼠类型（雌性斯普拉格 - 道利大鼠、雄性和雌性长埃文斯大鼠）的性腺切除术缩短了初始排斥时间；给予生理剂量的17β - 雌二醇加孕酮可使去卵巢大鼠的初始排斥时间恢复到未手术对照组的水平。由于二次卵巢切除术（垂体切除术）未缩短初始排斥时间，垂体切除大鼠给予性类固醇也未延长初始排斥时间，因此有人提出，卵巢切除术后免疫反应增强可能是由于存在一种免疫增强性垂体因子。尽管发现促卵泡激素、促黄体生成素和促黄体激素的商业制剂可模拟卵巢切除术的效果，但这些制剂的杂质（通过等电聚焦凝胶判断）使得无法就假定的免疫增强因子的性质得出任何结论。
