Illsley N P, Lamartiniere C A
Endocrinology. 1981 May;108(5):1737-43. doi: 10.1210/endo-108-5-1737.
Enzymological and endocrine studies of rat serum cholinesterase (CHE) suggest that this enzyme is subject to a complex and specific form of regulation. Adult CHE activity levels are 3-fold higher in adult females than in males. Gonadectomy and/or hypophysectomy abolish these sex differences. Androgen and estrogen replacement to gonadectomized but not to hypophysectomized animals reverses this action. Adrenalectomy produces no significant changes in serum CHE levels in either male or female rats. An ectopic pituitary plus the appropriate steroid cannot reverse the effect of hypophysectomy. The catalytic properties of CHE alter concurrently with isozyme changes and are reflected in the changes in the ratio of hydrolysis of the butyryl and acetyl substrates. Androgens and estrogens, acting through the hypothalamic-hypophyseal axis, appear to modulate the synthesis of specific CHE isozymes.
对大鼠血清胆碱酯酶（CHE）的酶学和内分泌学研究表明，该酶受到一种复杂且特定形式的调节。成年雌性大鼠的CHE活性水平比雄性高3倍。性腺切除和/或垂体切除可消除这些性别差异。对性腺切除但未垂体切除的动物进行雄激素和雌激素替代可逆转这种作用。肾上腺切除对雄性或雌性大鼠的血清CHE水平均无显著影响。异位垂体加上适当的类固醇不能逆转垂体切除的效果。CHE的催化特性与同工酶变化同时改变，并反映在丁酰和乙酰底物水解比例的变化中。雄激素和雌激素通过下丘脑 - 垂体轴发挥作用，似乎调节特定CHE同工酶的合成。
