Cinci G, Pizzichini M, Arezzini L, Pandolfi M L, Leoncini R, Terzuoli L, Vannoni D, Pagani R
Institute of Biochemistry and Enzymology, University of Siena, Italy.
Life Sci. 1995;56(1):39-44. doi: 10.1016/0024-3205(94)00405-h.
Total, free and esterified cholesterol and its fatty acid composition were measured in the serum lipoproteins of castrated rats after estradiol administration. In general, castration and treatment with estradiol led to a decrease in total esterified cholesterol content. However, estradiol induced an effect opposite to that of castration on the fatty acid composition in VLDL. The effects were variable in HDL and insignificant in LDL. Similarly, the ratios of essential fatty acid to non-essential fatty acid (EFA/NEFA) and that to monoenoic acid (EFA/ME) were affected differently in castration and estradiol treatment in VLDL, but not in HDL or LDL. The pattern of lipid metabolism in castrated and estradiol-treated rats thus appears opposite to that described in human pathology.
测定了给予雌二醇后去势大鼠血清脂蛋白中的总胆固醇、游离胆固醇、酯化胆固醇及其脂肪酸组成。总体而言，去势和雌二醇处理导致总酯化胆固醇含量降低。然而，雌二醇对极低密度脂蛋白（VLDL）中脂肪酸组成的影响与去势相反。高密度脂蛋白（HDL）中的影响存在差异，低密度脂蛋白（LDL）中的影响不显著。同样，在VLDL中，去势和雌二醇处理对必需脂肪酸与非必需脂肪酸的比例（EFA/NEFA）以及必需脂肪酸与单不饱和脂肪酸的比例（EFA/ME）的影响不同，但在HDL或LDL中则无差异。因此，去势和雌二醇处理大鼠的脂质代谢模式似乎与人类病理学中描述的相反。
