Arst H N, Bignell E, Tilburn J
Department of Infectious Diseases and Bacteriology, Royal Postgraduate Medical School, London, England.
Mol Gen Genet. 1994 Dec 15;245(6):787-90. doi: 10.1007/BF00297286.
Two new genes, palH and palI, where mutations mimic the effects of acidic growth pH have been identified in Aspergillus nidulans. A palH mutation is phenotypically indistinguishable from mutations in the palA, palB, palC, and palF genes, whereas palI mutations differ only in that they allow some growth at pH 8. Mutations in palA, B, C, F, and H are epistatic to a palI mutation and the significance of this epistasis is discussed. Additionally, palE and palB mutations have been shown to be allelic. Thus, a total of six genes where mutations mimic acidic growth conditions has been identified.
在构巢曲霉中已鉴定出两个新基因palH和palI，其突变模拟了酸性生长pH的影响。palH突变在表型上与palA、palB、palC和palF基因的突变无法区分，而palI突变的不同之处仅在于它们在pH 8时允许一些生长。palA、B、C、F和H的突变对palI突变是上位性的，并讨论了这种上位性的意义。此外，palE和palB突变已被证明是等位基因。因此，总共鉴定出六个突变模拟酸性生长条件的基因。
