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[一组未经筛选的男科患者中自体精子抗体的发生率]

[Incidence of autologous spermatozoa antibodies in a group of unselected andrologic patients].

作者信息

Schill W, Petzoldt D, Kammerl M

出版信息

Hautarzt. 1976 Aug;27(8):382-90.

PMID:783089
Abstract

Determination of autologous sperm antibodies in the serum of 278 male adults of an unselected andrological patient material is reported. Positive test results were found in 3 patients using the macroscopic agglutination test according to Kibrick (1.1%), in 21 patients using the microscopical agglutination test according to Franklin-Dukes (7.6%), in 2 patients using the immobilization test according to Isojima (0.7%) and in 1 patient using the indirect immunofluorescence technique according to Coons and Kaplan (0.4%). Comparing the macroscopic and microscopic agglutination test a high degree of unspecific agglutinations were found in the latter excluding the microscopical agglutination test for the determination of antibodies. The relatively rare occurrence of autologous sperm antibodies in an unselected andrological patient material points to the fact that immunological methods seem to play no significant role in the diagnosis of male subfertility.

摘要

报告了对278名未经选择的男科患者材料中的成年男性血清进行自体精子抗体检测的情况。采用基布里克宏观凝集试验,在3名患者中检测到阳性结果(1.1%);采用富兰克林-杜克斯显微镜凝集试验,在21名患者中检测到阳性结果(7.6%);采用矶岛精子制动试验,在2名患者中检测到阳性结果(0.7%);采用库恩斯和卡普兰间接免疫荧光技术,在1名患者中检测到阳性结果(0.4%)。比较宏观凝集试验和显微镜凝集试验发现,后者存在高度非特异性凝集,因此排除显微镜凝集试验用于抗体检测。在未经选择的男科患者材料中,自体精子抗体相对少见,这表明免疫方法在男性不育诊断中似乎没有显著作用。

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