dos Santos A C, Colacciopo S, Dal Bó C M, dos Santos N A
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Brazil.
Am J Ind Med. 1994 Nov;26(5):635-43. doi: 10.1002/ajim.4700260506.
In the present study we examined sensitive biochemical markers of kidney function and damage in 166 workers exposed to lead and in 60 control workers. The objective was to investigate the chronic renal toxicity of lead and its possible correlation with arterial pressure. Diastolic arterial pressure was higher in the exposed group (p < 0.05), but the two groups did not differ in systolic pressure. Median activity of urinary N-acetyl-beta-D-glucosaminidase was higher in the exposed group (p < 0.001), and correlated with blood lead levels (p < 0.001) and duration of exposure (p < 0.001), but not with arterial pressure. The other indicators studied, gamma-glutamyl-transpeptidase and alanine-aminopeptidase activity, urine albumin, and total urine protein, were not higher than in the control group and were not correlated with blood lead, duration of exposure, or arterial pressure.
在本研究中，我们检测了166名铅接触工人和60名对照工人的肾功能及损伤的敏感生化标志物。目的是研究铅的慢性肾毒性及其与动脉血压的可能相关性。暴露组的舒张压较高（p<0.05），但两组的收缩压无差异。暴露组尿N-乙酰-β-D-氨基葡萄糖苷酶的中位活性较高（p<0.001），且与血铅水平（p<0.001）和暴露时间（p<0.001）相关，但与动脉血压无关。所研究的其他指标，γ-谷氨酰转肽酶和丙氨酸氨基肽酶活性、尿白蛋白和尿总蛋白，均不高于对照组，且与血铅、暴露时间或动脉血压无关。
