抑制蛋白的结构与功能。
Structure and functions of arrestins.
作者信息
Palczewski K
机构信息
Department of Ophthalmology, University of Washington, Seattle 98195.
出版信息
Protein Sci. 1994 Sep;3(9):1355-61. doi: 10.1002/pro.5560030901.
Abstract
Transmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G proteins; and (4) effector enzymes or ion channels. Parallel to these amplification reactions, receptors are precisely inactivated by mechanisms that involve protein kinases and regulatory proteins called arrestins. The structure and functions of arrestins are the focus of this review.
摘要
多种细胞类型中的跨膜信号转导介导着与神经递质、激素和感觉信号所携带的信号一样多样的信号，它们共享基本的生化机制，包括：(1) 细胞外扰动（神经递质、激素、气味、光）；(2) 特异性受体；(3) 偶联蛋白，如G蛋白；以及(4) 效应酶或离子通道。与这些放大反应并行的是，受体通过涉及蛋白激酶和称为抑制蛋白的调节蛋白的机制被精确地失活。抑制蛋白的结构和功能是本综述的重点。
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