Matre R, Tönder O, Thunold S, Solhaug J H
Scand J Immunol. 1976;5(4):361-8. doi: 10.1111/j.1365-3083.1976.tb00290.x.
Properties of the IgG receptors were studied by treating tissue sections or suspensions of peripheral mononuclear cells with various chemical reagents and determining changes in their ability to react with IgG-sensitized erythrocytes (EA). A heterogeneity of the Fc receptors was revealed. Iodoacetamide, 2-mercaptoethanol, sodium azide, EDTA, and a pH varying from 6.0 to 8.2 had no effect on Fc receptors in sections of normal lymphoreticular tissue and malignant tissue. Formaldehyde, low pH, and high salt concentrations affected receptor activity to various degrees. Receptors in liver sections and on monocytes were generally more resistant than receptors in spleen sections and on B lymphocytes. Receptors in malignant tissue behaved either like receptors in spleen or like receptors in liver. Although all tissues were sensitive to periodic acid, the Fc receptors in malignant tissue were always more resistant.
通过用各种化学试剂处理外周单核细胞的组织切片或悬液，并测定它们与IgG致敏红细胞（EA）反应能力的变化，研究了IgG受体的特性。揭示了Fc受体的异质性。碘乙酰胺、2-巯基乙醇、叠氮化钠、乙二胺四乙酸以及pH值在6.0至8.2之间变化对正常淋巴网状组织和恶性组织切片中的Fc受体没有影响。甲醛、低pH值和高盐浓度对受体活性有不同程度的影响。肝切片和单核细胞上的受体通常比脾切片和B淋巴细胞上的受体更具抗性。恶性组织中的受体表现得要么像脾中的受体，要么像肝中的受体。尽管所有组织对高碘酸都敏感，但恶性组织中的Fc受体总是更具抗性。
