Kendrick Z V, Affrime M B, Lowenthal D T
Biokinetics Research Laboratory, HPERD College, Temple University, Philadelphia, Pennsylvania 19122.
Int J Clin Pharmacol Ther. 1994 Oct;32(10):536-41.
The effects of caffeine and ethanol on treadmill performance and metabolic responses to exercise were determined in four trained runners. Caffeine (2.5 mg.kg-1 body weight) or ethanol (25 ml) in 150 ml of grapefruit juice (total volume) or grapefruit juice (placebo) was randomly administered 10 minutes prior to and at 30 minutes of a 60 minutes treadmill run. The speed and grade of the treadmill was adjusted to elicit an average oxygen consumption of 80-85% of the subject's maximal oxygen consumption. All subjects completed the treadmill run for the caffeine and placebo conditions. Three of the four subjects could not complete the treadmill run following the second administration of ethanol. Exercise heart rate was significantly greater for the ethanol condition than for the placebo condition. Exercise oxygen consumption was greater following ethanol administration than for placebo, but the differences were not significant. Blood glucose rose significantly between 0 and 30 minutes of treadmill running for all three conditions. Between 30 minutes of treadmill running and either 60 minutes or the time of termination of the exercise, blood glucose decreased significantly by 24% following the second ethanol treatment. Plasma fatty acid, triglyceride, creatine phosphokinase, and renin contents followed expected exercise changes with a blunting of the rise of plasma fatty acids at 30 minutes of exercise for the ethanol condition. It was concluded that the administration of ethanol adversely influenced treadmill exercise performance by eliciting a hypoglycemic effect between 30 minutes and the termination of the exercise.
在四名训练有素的跑步者中，研究了咖啡因和乙醇对跑步机运动表现以及运动代谢反应的影响。在60分钟跑步机跑步前10分钟和跑步30分钟时，随机给予受试者150毫升葡萄柚汁（总体积）中的咖啡因（2.5毫克/千克体重）或乙醇（25毫升），或给予葡萄柚汁（安慰剂）。调整跑步机的速度和坡度，以使受试者的平均耗氧量达到其最大耗氧量的80 - 85%。所有受试者都完成了咖啡因和安慰剂条件下的跑步机跑步。四名受试者中有三名在第二次给予乙醇后无法完成跑步机跑步。乙醇条件下的运动心率显著高于安慰剂条件。乙醇给药后的运动耗氧量高于安慰剂，但差异不显著。在所有三种条件下，跑步机跑步0至30分钟期间血糖显著升高。在跑步机跑步30分钟至60分钟或运动结束时，第二次乙醇处理后血糖显著下降24%。血浆脂肪酸、甘油三酯、肌酸磷酸激酶和肾素含量随运动呈现预期变化，乙醇条件下在运动30分钟时血浆脂肪酸升高有所减弱。研究得出结论，乙醇给药通过在运动30分钟至运动结束期间引发低血糖效应，对跑步机运动表现产生不利影响。
