Kendrick Z V, Affrime M B, Lowenthal D T
Biokinetics Research Laboratory, HPERD College, Temple University, Philadelphia, Pennsylvania 19122.
J Clin Pharmacol. 1993 Feb;33(2):136-9. doi: 10.1002/j.1552-4604.1993.tb03933.x.
The metabolic effects of ethanol on treadmill performance were determined in four trained runners. Ethanol in doses of 25 mL in 150 mL of grapefruit juice (total volume) or grapefruit juice was randomly administered 10 minutes before and at 30 minutes of a 60-minute treadmill run. The speed and grade of the treadmill was adjusted to elicit an average oxygen consumption (VO2) of 80 to 85% of the subjects' VO2max. Three of the four subjects could not complete the treadmill run after the administration of ethanol. Administration of ethanol resulted in significant increases in the heart rate responses to treadmill running above those for the placebo grapefruit treatment. VO2 was higher after ethanol administration than the placebo grapefruit juice treatment, but these values were not significant. Blood glucose content rose significantly between 0 and 30 minutes of treadmill running for both the ethanol and placebo grapefruit juice treatments. Between 30 minutes of treadmill running and the termination of the exercise, the blood glucose level decreased significantly by 24% after the second ethanol treatment at 30 minutes of exercise. Plasma fatty acid, triglyceride, creatine phosphokinase, and renin contents followed expected exercise changes. It was concluded that the administration of ethanol adversely influenced treadmill exercise performance by eliciting a hypoglycemic effect between 30 minutes and the termination of the exercise.
在四名训练有素的跑步者身上测定了乙醇对跑步机运动表现的代谢影响。在60分钟跑步机跑步前10分钟以及跑步30分钟时，随机给予150毫升葡萄柚汁（总体积）中含25毫升乙醇的饮品或单纯葡萄柚汁。跑步机的速度和坡度进行调整，以使平均耗氧量（VO2）达到受试者最大耗氧量（VO2max）的80%至85%。四名受试者中有三名在饮用乙醇后无法完成跑步机跑步。饮用乙醇后，跑步机跑步时的心率反应显著高于安慰剂葡萄柚汁处理组。饮用乙醇后的VO2高于安慰剂葡萄柚汁处理组，但这些数值并无显著差异。对于乙醇处理组和安慰剂葡萄柚汁处理组，在跑步机跑步的0至30分钟期间，血糖含量均显著升高。在跑步机跑步30分钟至运动结束期间，在运动30分钟时第二次给予乙醇后，血糖水平显著下降了24%。血浆脂肪酸、甘油三酯、肌酸磷酸激酶和肾素含量呈现出预期的运动变化。研究得出结论，饮用乙醇通过在运动30分钟至结束期间引发低血糖效应，对跑步机运动表现产生了不利影响。
