Tremblay F, De Becker I, Riddell D C, Dooley J M
Department of Ophthalmology, Dalhousie University, Halifax, NS.
Can J Ophthalmol. 1994 Dec;29(6):280-3.
Recent reports indicate that most subjects with Duchenne muscular dystrophy (DMD) have a negative scotopic bright-flash electroretinogram (ERG). We performed dark adaptometry in seven patients with the DMD phenotype. Three patients had the negative bright-flash response combined with severely reduced rod-related activity; their mean psychophysical dark-adapted threshold was -5.5 +/- 0.3 (normally -5.4 +/- 0.3) cd.m-2. Two of the three patients were able to sit through the complete test: the profile of their dark adaptation curve was normal. The four other patients had a normal scotopic ERG, and their mean psychophysical dark-adapted threshold was -5.3 +/- 0.3 cd.m-2. One of the four was able to complete the entire procedure, and a normal profile was found. In patients with DMD the dark adaptation measurements are normal despite abnormalities in rod-related ERG activity.
近期报告表明，大多数杜氏肌营养不良症（DMD）患者的暗视闪光视网膜电图（ERG）呈阴性。我们对7例具有DMD表型的患者进行了暗适应测定。3例患者的闪光反应呈阴性，同时与视杆细胞相关的活动严重降低；他们心理物理学暗适应阈值的平均值为-5.5±0.3（正常为-5.4±0.3）cd.m-2。这3例患者中有2例能够全程完成测试：他们暗适应曲线的形态正常。另外4例患者的暗视ERG正常，其心理物理学暗适应阈值的平均值为-5.3±0.3 cd.m-2。这4例患者中有1例能够完成整个测试过程，且发现其曲线形态正常。在DMD患者中，尽管视杆细胞相关的ERG活动存在异常，但暗适应测量结果正常。
