Zhuang S M, Shvarts A, van Ormondt H, Jochemsen A G, van der Eb A J, Noteborn M H
Laboratory of Molecular Carcinogenesis, Sylvius Laboratories, Leiden University, The Netherlands.
Cancer Res. 1995 Feb 1;55(3):486-9.
Previously, we have shown that the chicken anemia virus-derived VP3 ("apoptin") protein induces apoptosis in chicken mononuclear cells. Here, we report that apoptin also induces apoptosis in human osteosarcoma cells, regardless of whether they expressed wild-type, mutant p53, or no p53 at all. Moreover, the nuclear location of apoptin appears to be important for its optimal induction of apoptosis. The fact that apoptin can induce p53-independent apoptosis in human tumor cells makes apoptin a potential candidate for treatment of frequently occurring types of cancer cells that do not contain functional p53.
此前，我们已经表明，源自鸡贫血病毒的VP3（“凋亡素”）蛋白可诱导鸡单核细胞凋亡。在此，我们报告凋亡素也可诱导人骨肉瘤细胞凋亡，无论这些细胞表达野生型、突变型p53还是根本不表达p53。此外，凋亡素的核定位似乎对其最佳诱导凋亡作用很重要。凋亡素可在人肿瘤细胞中诱导不依赖p53的凋亡这一事实，使凋亡素成为治疗不含功能性p53的常见类型癌细胞的潜在候选物。
