Boulanger B R, Lloyd S J, Walker M, Johnston M G
Trauma Research Division, Sunnybrook Health Science Centre, University of Toronto, Canada.
Circ Shock. 1994 Jun;43(2):95-101.
Lymphatic vessels have the ability to contract and transport liquid and protein from tissue spaces to the intravascular space. The purpose of this investigation was to test whether this lymph pump is stimulated following a fixed volume hemorrhage in awake sheep. To quantitate lymphatic pumping in vivo, a mesenteric lymphatic was isolated from all lymph input and provided with Krebs solution at a fixed transmural pressure. A branch of the mesenteric duct was cannulated to provide a measure of lymph flow rate. Each animal was either bled 25% of blood volume over 5 min or was observed. Systemic arterial blood pressure declined in all bled sheep (P < 0.05). Hemorrhage had no effect on lymph flow from mesenteric ducts. However, hemorrhage significantly enhanced lymphatic pumping, approximately 200% of control values 3 hr after hemorrhage (P < 0.01). Increased lymphatic pumping after hemorrhage may play an important role in blood volume and protein restitution.
淋巴管具有收缩能力，并能将液体和蛋白质从组织间隙输送到血管内空间。本研究的目的是测试清醒绵羊在固定容量出血后这种淋巴泵是否会受到刺激。为了在体内定量淋巴泵功能，将一段肠系膜淋巴管与所有淋巴输入隔离，并在固定的跨壁压力下给予 Krebs 溶液。将肠系膜导管的一个分支插管以测量淋巴流速。每只动物要么在 5 分钟内失血 25% 的血容量，要么作为对照进行观察。所有失血绵羊的全身动脉血压均下降（P < 0.05）。出血对肠系膜导管的淋巴流量没有影响。然而，出血显著增强了淋巴泵功能，出血后 3 小时约为对照值的 200%（P < 0.01）。出血后淋巴泵功能增强可能在血容量和蛋白质恢复中起重要作用。
