Xu Z, Xu W, Chen Z
Institute of Acupuncture, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1994;19(1):16-9.
Using the techniques of multimicropipette and iontophoresis, we observed whether ACh was involved in the cortical descending modulation of Pf neurons in rats. It was shown that the inhibition elicited by stimulation of the sensorimotor area (SmI) was attenuated after microiontophoretic atropine and that the nociceptive responses of Pf neurons were obviously reduced by microiontophoretic ACh. Therefore, it suggests that ACh may be considered as one of the neurotransmitters involved in the descending modulation of pain.
运用多管微量移液法和离子导入技术，我们观察了乙酰胆碱（ACh）是否参与大鼠中脑导水管周围灰质（Pf）神经元的皮质下行调制。结果显示，微量离子导入阿托品后，刺激感觉运动区（SmI）所诱发的抑制作用减弱，且微量离子导入ACh可明显降低Pf神经元的伤害性反应。因此，这表明乙酰胆碱可能被视为参与疼痛下行调制的神经递质之一。
