Zheng X, Xu W, Chen Z
Institute of Acupuncture, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1995;20(1):10-4.
The effect of opioid peptides on corticofugal modulation of nociceptive response in thalamic ventrobasal nucleus (VB) produced by cortical sensorimotor area II (Sm II) was observed. Single unit activities of VB neurons were extracellularly recorded by glass microelectrodes. The results showed that the nociceptive responses of VB neurons were attenuated at 0-7.5 minutes after stimulating Sm II (n = 14, P < 0.05). The inhibitory effect of stimulation of Sm II was reduced after ventriculer microinjection of 20ul of naloxone (n = 9), while marked inhibition was shown at 0-2.5 minutes after stimulating Sm II in the saline control group (n = 9, P < 0.05). There was a statistical difference at 0-2.5 minutes after stimulating Sm II between the two groups (P < 0.05). These studies suggest that opioid peptides might be involved in corticofugal modulation of pain.
观察了阿片肽对皮质感觉运动区II（Sm II）产生的丘脑腹侧基底核（VB）伤害性反应的皮质离心调制作用。用玻璃微电极细胞外记录VB神经元的单位活动。结果显示，刺激Sm II后0 - 7.5分钟，VB神经元的伤害性反应减弱（n = 14，P < 0.05）。脑室微量注射20μl纳洛酮后，刺激Sm II的抑制作用减弱（n = 9），而在生理盐水对照组（n = 9，P < 0.05）中，刺激Sm II后0 - 2.5分钟显示出明显的抑制作用。两组在刺激Sm II后0 - 2.5分钟存在统计学差异（P < 0.05）。这些研究表明，阿片肽可能参与疼痛的皮质离心调制。
