衰老对人和大鼠血浆1,5-脱水葡萄糖醇水平的影响。

Effect of aging on plasma 1,5-anhydroglucitol levels in humans and rats.

作者信息

Funasako M, Taniji M, Fujimoto K, Ohata M, Higashimoto Y, Uetani K, Suruda T, Nakai S, Fujimoto H, Sakagami Y

机构信息

Department of Internal Medicine, Wakayama Medical College Kihoku Hospital, Japan.

出版信息

Diabetes Res Clin Pract. 1994 Aug;25(1):35-41. doi: 10.1016/0168-8227(94)90159-7.

DOI:10.1016/0168-8227(94)90159-7

PMID:7835210

Abstract

Since normal reference values change with age in some clinical parameters, we measured the plasma levels of 1,5-anhydroglucitol (AG), a new marker of glycemic control in diabetes mellitus, in healthy subjects and in rats. Our results showed a significantly negative correlation of the marker with age in humans and that the plasma AG levels of older rats were markedly lower than those of younger counterparts. This remarkable reduction of AG in the older rat group can be partially explained by our finding that aged animals excreted AG more rapidly in the urine than younger ones, besides a decrease in food intake. We therefore suggest that normal clinical reference values for plasma AG levels should be modified according to age.

摘要

由于某些临床参数的正常参考值会随年龄变化，我们测定了健康受试者和大鼠体内1,5-脱水葡萄糖醇（AG）的血浆水平，AG是糖尿病血糖控制的一种新标志物。我们的结果显示，该标志物在人类中与年龄呈显著负相关，且老年大鼠的血浆AG水平明显低于年轻大鼠。老年大鼠组中AG的显著降低，除了食物摄入量减少外，部分原因可能是我们发现老年动物比年轻动物尿液中AG的排泄速度更快。因此，我们建议血浆AG水平的正常临床参考值应根据年龄进行调整。