Yamanouchi T, Akanuma Y
Second Department of Internal Medicine, University of Teikyo, Tokyo, Japan.
Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S261-8. doi: 10.1016/0168-8227(94)90259-3.
We review the use of 1,5-anhydroglucitol (1,5 AG) in diagnosing and monitoring patients with diabetes. This six-carbon chain monosaccharide is one of the major polyols present in humans. Its concentration in serum is normally about 12 to 40 micrograms/ml. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues. It is metabolically stable, being excreted in the urine when its level exceeds the renal threshold. It is reabsorbed in the renal tubules, and is competitively inhibited by glucosuria, which leads to a reduction in its level in serum. The correlation between this reduction and the amount of glucose present in urine is so close that 1,5 AG can be used as a sensitive, day-to-day, real-time marker of glycemic control. It provides useful information on current glycemic control and is superior to both HbA1c and fructosamine in detecting near-normoglycemia.
我们综述了1,5 - 脱水葡萄糖醇（1,5 - AG）在糖尿病患者诊断和监测中的应用。这种六碳链单糖是人体内主要的多元醇之一。其血清浓度通常约为12至40微克/毫升。该物质主要来源于食物，在肠道中吸收良好，并分布于所有器官和组织。它在代谢上稳定，当其水平超过肾阈值时会随尿液排出。它在肾小管中被重吸收，并受到糖尿的竞争性抑制，这导致其血清水平降低。这种降低与尿中葡萄糖含量之间的相关性非常紧密，以至于1,5 - AG可作为血糖控制的敏感、日常、实时指标。它提供了有关当前血糖控制的有用信息，并且在检测接近正常血糖水平方面优于糖化血红蛋白（HbA1c）和果糖胺。
