Yamanouchi T, Akanuma H, Nakamura T, Akaoka I, Akanuma Y
Department of Internal Medicine, University of Teikyo, Japan.
Diabetologia. 1988 Jan;31(1):41-5. doi: 10.1007/BF00279131.
The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnosed diabetic patients, 229 normal subjects and 200 patients with various other disorders. The mean plasma AG concentration in diabetes mellitus was 1.9 +/- 1.8 micrograms/ml (mean +/- SD), which was definitely lower than that in healthy subjects and patients with other diseases including some metabolic and hormonal diseases (mean value range: 13.4-28.3 micrograms/ml). Only the "malignancies" group showed statistically different mean values from that in normal subjects; however, these values were much higher than those of diabetic patients. The AG concentration seemed to be relatively low in some severe by uraemic patients, but is likely to be little influenced by the glomerular filtration rate. Upon adjustment for sex and age, AG concentration was not found to be correlated with the degree of obesity in both healthy subjects and diabetic patients. The plasma AG concentration showed a tendency to be higher in healthy males than in healthy females in all age-matched groups; however, statistically significant differences were not seen. Also, no significant influence of age was observed.
已知糖尿病患者血浆中1,5 - 脱水 - D - 葡萄糖醇（AG）（1 - 脱氧葡萄糖）的浓度会降低。为了评估这种多元醇作为糖尿病标志物的有效性，我们研究了各种疾病中血浆AG降低的特异性：测定了108例新诊断糖尿病患者、229名正常受试者和200例患有其他各种疾病患者的血浆AG水平。糖尿病患者的血浆AG平均浓度为1.9±1.8微克/毫升（平均值±标准差），明显低于健康受试者以及包括一些代谢和激素疾病在内的其他疾病患者（平均值范围：13.4 - 28.3微克/毫升）。只有“恶性肿瘤”组的平均值与正常受试者有统计学差异；然而，这些值远高于糖尿病患者。在一些重症尿毒症患者中，AG浓度似乎相对较低，但可能受肾小球滤过率影响较小。在对性别和年龄进行校正后，未发现健康受试者和糖尿病患者的AG浓度与肥胖程度相关。在所有年龄匹配组中，健康男性的血浆AG浓度均有高于健康女性的趋势；然而，未观察到统计学上的显著差异。此外，未观察到年龄的显著影响。
