Li Z, Bonney G E, Rao D C
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri.
Genet Epidemiol. 1994;11(5):431-42. doi: 10.1002/gepi.1370110505.
We have extended the class D regressive model for the purpose of combined path and segregation analyses by incorporating the BETA path model. We have done this by expressing correlations among residuals from major genotype (RMGs) of family members under the class D regressive model as functions of path coefficients under the BETA path model. The likelihood function under the combined model was factorized into a product of conditional densities, which is dominated by bivariate normal densities. Statistical inferences under the combined model are analogous to those under the class D regressive model.
为了进行联合路径分析和分离分析，我们通过纳入BETA路径模型扩展了D类回归模型。我们通过将D类回归模型下家庭成员主要基因型（RMGs）残差之间的相关性表示为BETA路径模型下路径系数的函数来实现这一点。联合模型下的似然函数被分解为条件密度的乘积，其主要由二元正态密度主导。联合模型下的统计推断与D类回归模型下的统计推断类似。
