口服免疫大鼠的CD4 + T细胞在增强从肺部清除铜绿假单胞菌中的作用。
A role for CD4+ T cells from orally immunized rats in enhanced clearance of Pseudomonas aeruginosa from the lung.
作者信息
Dunkley M L, Clancy R L, Cripps A W
机构信息
Faculty of Medicine and Health Science, University of Newcastle, Callaghan, New South Wales, Australia.
出版信息
Immunology. 1994 Nov;83(3):362-9.
Abstract
The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently challenged intra-tracheally with live P. aeruginosa. Recipients of unseparated mesenteric lymph node cells, purifed T cells or CD4+ T cells, from P. aeruginosa-immunized donors, all exhibited enhanced bacterial clearance from the airways compared to recipients of cells from unimmunized donors. Enhanced clearance by T cells was antigen-specific as no enhanced clearance was observed by transfer of cells from donors immunized with H. pylori.
摘要
通过细胞转移实验研究了肠道来源的CD4 + T细胞在清除肺部铜绿假单胞菌中的作用。将来自未免疫大鼠、或经灭活铜绿假单胞菌或幽门螺杆菌口服免疫的大鼠的肠系膜淋巴结细胞，转移至随后经气管内接种活铜绿假单胞菌的未免疫大鼠。与来自未免疫供体的细胞受体相比，来自铜绿假单胞菌免疫供体的未分离肠系膜淋巴结细胞、纯化T细胞或CD4 + T细胞的受体，均表现出气道细菌清除增强。T细胞介导的清除增强具有抗原特异性，因为转移来自幽门螺杆菌免疫供体的细胞未观察到清除增强。
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本文引用的文献
1
Effector mechanisms of intestinally induced immunity to Pseudomonas aeruginosa in the rat lung: role of neutrophils and leukotriene B4.大鼠肺脏中肠道诱导的对铜绿假单胞菌免疫的效应机制：中性粒细胞和白三烯B4的作用
Infect Immun. 1993 Feb;61(2):671-9. doi: 10.1128/iai.61.2.671-679.1993.
2
The immunoevasive activities of Pseudomonas aeruginosa. Relevance for cystic fibrosis.铜绿假单胞菌的免疫逃避活性。与囊性纤维化的相关性。
Am Rev Respir Dis. 1993 Sep;148(3):793-805. doi: 10.1164/ajrccm/148.3.793.
3
Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats.用灭活铜绿假单胞菌进行黏膜和全身免疫可预防大鼠急性呼吸道感染。
Infect Immun. 1994 Apr;62(4):1427-36. doi: 10.1128/iai.62.4.1427-1436.1994.
4
Two subsets of rat T lymphocytes defined with monoclonal antibodies.用单克隆抗体定义的大鼠T淋巴细胞的两个亚群。
Eur J Immunol. 1980 Aug;10(8):609-15. doi: 10.1002/eji.1830100807.
5
6
Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis.囊性纤维化患者对铜绿假单胞菌抗原免疫反应的纵向研究。
Infect Immun. 1983 Oct;42(1):197-201. doi: 10.1128/iai.42.1.197-201.1983.
7
Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies.用单克隆抗体分离的大鼠T淋巴细胞亚群的功能。
Immunol Rev. 1983;74:57-82. doi: 10.1111/j.1600-065x.1983.tb01084.x.
8
9
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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