Dunkley M L, Clancy R L, Cripps A W
Faculty of Medicine and Health Science, University of Newcastle, Callaghan, New South Wales, Australia.
Immunology. 1994 Nov;83(3):362-9.
The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently challenged intra-tracheally with live P. aeruginosa. Recipients of unseparated mesenteric lymph node cells, purifed T cells or CD4+ T cells, from P. aeruginosa-immunized donors, all exhibited enhanced bacterial clearance from the airways compared to recipients of cells from unimmunized donors. Enhanced clearance by T cells was antigen-specific as no enhanced clearance was observed by transfer of cells from donors immunized with H. pylori.
通过细胞转移实验研究了肠道来源的CD4 + T细胞在清除肺部铜绿假单胞菌中的作用。将来自未免疫大鼠、或经灭活铜绿假单胞菌或幽门螺杆菌口服免疫的大鼠的肠系膜淋巴结细胞，转移至随后经气管内接种活铜绿假单胞菌的未免疫大鼠。与来自未免疫供体的细胞受体相比，来自铜绿假单胞菌免疫供体的未分离肠系膜淋巴结细胞、纯化T细胞或CD4 + T细胞的受体，均表现出气道细菌清除增强。T细胞介导的清除增强具有抗原特异性，因为转移来自幽门螺杆菌免疫供体的细胞未观察到清除增强。
