Beck R, Lam-Po-Tang P R
Bone Marrow Transplant Laboratory, Prince of Wales Children's Hospital, Randwick, New South Wales, Australia.
Immunol Cell Biol. 1994 Oct;72(5):440-4. doi: 10.1038/icb.1994.65.
Lymphocyte subpopulations in cord blood (CB; collected at birth from full-term babies) were compared with that of adult blood (AB) and found to contain significantly different numbers and percentages of lymphocyte subpopulations. The absolute lymphocyte count was greater in CB (4.8 +/- 1.1 x 10(9)/L) than in AB (1.69 +/- 0.38 x 10(9)/L), with CB having significantly higher absolute numbers of lymphocyte subsets even though CB percentages were significantly lower. Significant differences in percentages were found between cord and adult T cells (CB 58% vs AB 74%), NK cells (CB 19% vs AB 7%) and their subsets. CD38, a marker of activation and immaturity, was present on virtually all cord T cells and approximately half the adult T cells. CD45RA, a marker considered to define unprimed or naive cells, was expressed on 82% of cord lymphocytes as compared with 48% in AB. CD45RO was expressed on 16% of CB lymphocytes and 49% of AB lymphocytes. Cord blood contains a higher percentage and total number of immature and immunologically naive lymphocytes than AB.
对脐血（CB；从足月婴儿出生时采集）中的淋巴细胞亚群与成人血液（AB）中的淋巴细胞亚群进行了比较，发现两者的淋巴细胞亚群数量和百分比存在显著差异。脐血中的绝对淋巴细胞计数（4.8±1.1×10⁹/L）高于成人血液（1.69±0.38×10⁹/L），尽管脐血中淋巴细胞亚群的百分比显著较低，但其淋巴细胞亚群的绝对数量却明显更高。在脐血和成人的T细胞（脐血58% vs成人74%）、NK细胞（脐血19% vs成人7%）及其亚群之间发现了百分比的显著差异。CD38是激活和不成熟的标志物，几乎所有脐血T细胞和大约一半的成人T细胞上都有表达。CD45RA是一种被认为可定义未致敏或幼稚细胞的标志物，82%的脐血淋巴细胞表达该标志物，而成人血液中这一比例为48%。16%的脐血淋巴细胞表达CD45RO，成人血液中这一比例为49%。与成人血液相比，脐血中不成熟和免疫幼稚淋巴细胞的百分比和总数更高。
