Klausner R D, Handler S D
Division of Otolaryngology, Children's Hospital of Philadelphia, PA.
Int J Pediatr Otorhinolaryngol. 1994 Nov;30(3):205-10. doi: 10.1016/0165-5876(94)90061-2.
Pleomorphic adenoma is the most common neoplasm found in the parotid gland. The familial occurrence of any salivary gland neoplasm is rare. There are 8 previous reports in the literature of familial occurrence of salivary gland tumors. Two of these report the occurrence of pleomorphic adenoma of the parotid gland in siblings; all 4 patients were adults. We report here an 11-year-old male who presented with a left parotid mass and underwent parotidectomy. The mass proved to be a pleomorphic adenoma. His sister presented 9 years later at the age of 15 years with a similar mass also in the left parotid area. She underwent superficial parotidectomy which revealed the mass to be a pleomorphic adenoma. We believe these are the youngest siblings reported to date in which familial pleomorphic adenoma has occurred.
多形性腺瘤是腮腺中最常见的肿瘤。任何涎腺肿瘤的家族性发病都很罕见。文献中此前有8篇关于涎腺肿瘤家族性发病的报道。其中两篇报道了兄弟姐妹中发生腮腺多形性腺瘤；所有4例患者均为成年人。我们在此报告一名11岁男性，他因左侧腮腺肿块就诊并接受了腮腺切除术。肿块被证实为多形性腺瘤。9年后，他15岁的姐姐也在左侧腮腺区域出现了类似肿块。她接受了腮腺浅叶切除术，结果显示肿块为多形性腺瘤。我们认为这是迄今为止报道的发生家族性多形性腺瘤的最年轻的兄弟姐妹。
