Fukushima T, Ikeda T, Uyama E, Uchino M, Okabe H, Ando M
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
J Neurol Sci. 1994 Oct;126(1):30-9. doi: 10.1016/0022-510x(94)90091-4.
Auditory and visual cognitive event-related potentials (ERPs) were investigated in 14 patients with HTLV-1 associated myelopathy (HAM) and in 36 normal controls. In the HAM patients, the latencies of P300 and N200 by the auditory tone method were significantly delayed, and N100 by the auditory click method was significantly delayed in latency. No abnormal ERP components were observed with visual methods. While these auditory abnormal ERPs were present in the HAM patients, there was no evidence of visual abnormal ERPs. Abnormal lesions on the white matter were evident at magnetic resonance imaging (MRI) in 6 (75%) of 8 patients. There was no correlation between MRI lesions and the abnormalities of ERPs, but there was a significant correlation between bifrontal index on MRI and P300 amplitudes at Cz and Pz sites by auditory tone method. In one patient, atrophy of bilateral parietal lobes was seen on MRI and P300 latencies delayed using various methods. Therefore, the possibility that electrophysiological cognitive impairment in patients with HAM is related to brain atrophy rather than to white matter lesions requires attention.
对14例人类T淋巴细胞病毒1型（HTLV-1）相关脊髓病（HAM）患者和36名正常对照者进行了听觉和视觉认知事件相关电位（ERP）研究。在HAM患者中，采用听觉纯音法时P300和N200的潜伏期显著延迟，采用听觉点击法时N100的潜伏期显著延迟。视觉方法未观察到异常ERP成分。虽然HAM患者存在这些听觉异常ERP，但没有视觉异常ERP的证据。8例患者中有6例（75%）在磁共振成像（MRI）上可见白质异常病变。MRI病变与ERP异常之间无相关性，但MRI上的双额叶指数与采用听觉纯音法在Cz和Pz部位的P300波幅之间存在显著相关性。1例患者MRI显示双侧顶叶萎缩，采用多种方法时P300潜伏期延迟。因此，HAM患者的电生理认知障碍与脑萎缩而非白质病变有关的可能性值得关注。
