Hernández-Pando R, Reyes P, Espitia C, Wang Y, Rook G, Mancilla R
Departamento de Patologia, Instituto Nacional de Enfermedades de la Nutrición, Mexico City, México, D.F.
J Rheumatol. 1994 Oct;21(10):1870-6.
Takayasu's arteritis is an inflammatory occlusive disease of the aorta and its main branches of unknown etiology. Some suggested causes include inapparent infection with Mycobacterium tuberculosis, or autoimmunity evoked by this organism. We have therefore sought links with mycobacterial disease.
We assayed the % agalactosyl IgG, antibody to a tuberculosis-specific 38 kDa protein, and antibody to the mycobacterial 65 kDa heat shock protein (HSP), in patients with active or inactive Takayasu's arteritis, in whom the diagnosis of tuberculosis was excluded. The results were compared with findings in tuberculosis (positive controls), normal donors and patients with Wegener's granulomatosis.
The % agalactosyl IgG in patients with active arteritis was in the range previously seen only in rheumatoid arthritis, Crohn's disease, and the mycobacterioses. Similarly, significantly raised antibody to the purified 38-kDa protein of M. tuberculosis, and to the 65-kDa HSP of M. leprae, was found in 78% of patients with Takayasu's arteritis, and the levels were higher in those with active disease.
These results suggest that Takayasu's arteritis particularly clearly illustrates the occasional relationship between mycobacteria and diseases of superficially autoimmune pathogenesis.
高安动脉炎是一种病因不明的主动脉及其主要分支的炎性闭塞性疾病。一些推测的病因包括隐匿性结核分枝杆菌感染，或该病原体引发的自身免疫。因此，我们探寻了与分枝杆菌病的联系。
我们检测了已排除结核病诊断的活动期或非活动期高安动脉炎患者的无半乳糖基IgG百分比、结核特异性38 kDa蛋白抗体以及分枝杆菌65 kDa热休克蛋白（HSP）抗体。将结果与结核病患者（阳性对照）、正常供者以及韦格纳肉芽肿病患者的检测结果进行比较。
活动期动脉炎患者的无半乳糖基IgG百分比处于之前仅在类风湿关节炎、克罗恩病和分枝杆菌病中出现的范围。同样，在78%的高安动脉炎患者中发现结核分枝杆菌纯化38 kDa蛋白抗体和麻风分枝杆菌65 kDa HSP抗体显著升高，且活动期疾病患者的抗体水平更高。
这些结果表明，高安动脉炎特别清晰地说明了分枝杆菌与表面上具有自身免疫发病机制的疾病之间偶尔存在的关系。
