Taddio A, Goldbach M, Ipp M, Stevens B, Koren G
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada.
Lancet. 1995 Feb 4;345(8945):291-2. doi: 10.1016/s0140-6736(95)90278-3.
Using data from one of our randomised trials, we investigated post-hoc whether male neonatal circumcision is associated with a greater pain response to routine vaccination at 4 or 6 months. Pain response during routine vaccination with diphtheria-pertussis-tetanus (DPT) alone or DPT followed by Haemophilus influenzae type b conjugate (HIB) was scored blind. 42 boys received DPT and 18 also received HIB. After DPT, median visual analogue scores by an observer were higher in the circumcised group (40 vs 26 mm, p = 0.03). After HIB, circumcised infants had higher behavioural pain scores (8 vs 6, p = 0.01) and cried longer (53 vs 19 s, p = 0.02). Thus neonatal circumcision may affect pain response several months after the event.
利用我们一项随机试验的数据，我们事后调查了男性新生儿包皮环切术是否与4个月或6个月时对常规疫苗接种的疼痛反应更大有关。仅对白喉-百日咳-破伤风（DPT）或DPT之后再接种b型流感嗜血杆菌结合疫苗（HIB）进行常规疫苗接种时的疼痛反应进行了盲法评分。42名男孩接种了DPT，其中18名还接种了HIB。接种DPT后，观察者的视觉模拟评分中位数在包皮环切组中更高（40对26毫米，p = 0.03）。接种HIB后，包皮环切的婴儿行为疼痛评分更高（8对6，p = 0.01），哭闹时间更长（53对19秒，p = 0.02）。因此，新生儿包皮环切术可能在术后数月影响疼痛反应。
