Wassef M, Achouche J, Guichard J P, Tran Ba Huy P
Department of Pathology, Hôpital Lariboisière, Paris, France.
ORL J Otorhinolaryngol Relat Spec. 1994 Nov-Dec;56(6):352-6. doi: 10.1159/000276691.
Pseudotumoral granulomatous foreign body reaction to Teflon particles is a rare complication of intracordal Teflon paste injection for unilateral vocal cord paralysis. We report a case of pseudotumor of the thyroid area, which appeared 3 years after intracordal Teflon paste injection and presented as a cold thyroid nodule. At frozen section examination the presence of a giant-cell foreign body granuloma containing numerous refringent particles suggested a 'teflonoma'. The diagnosis was confirmed on permanent sections, after comparison of the intratissular particles with fresh Teflon paste, under conventional and polarized light. The histological and ultrastructural features of the lesion are presented and attention is drawn to the long delay between initial Teflon injection and the clinical manifestation of the lesion.
聚四氟乙烯颗粒引起的假瘤样肉芽肿性异物反应是声带内注射聚四氟乙烯糊剂治疗单侧声带麻痹的一种罕见并发症。我们报告一例甲状腺区域假瘤病例，该病例在声带内注射聚四氟乙烯糊剂3年后出现，表现为甲状腺冷结节。在冰冻切片检查中，发现一个含有大量折光颗粒的巨细胞异物肉芽肿，提示为“聚四氟乙烯瘤”。在常规光镜和偏振光下，将组织内颗粒与新鲜聚四氟乙烯糊剂进行比较后，在永久切片上确诊。本文展示了病变的组织学和超微结构特征，并提请注意最初聚四氟乙烯注射与病变临床表现之间的长时间延迟。
